Yeast cells undergo programed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation. Though significant research has focused on mitochondrial involvement in this phenomenon, more recent work with both Saccharomyces cerevisiae and Schizosaccharomyces pombe has also implicated the endoplasmic reticulum (ER) in yeast PCD. This minireview provides an overview of ER stress-associated cell death (ER-SAD) in yeast. It begins with a description of ER structure and function in yeast before moving to a discussion of ER-SAD in both mammalian and yeast cells. Three examples of yeast cell death associated with the ER will be highlighted here including inositol starvation, lipid toxicity, and the inhibition of N-glycosylation. It closes by suggesting ways to further examine the involvement of the ER in yeast cell death.
Keywords: BXI1, endoplasmic reticulum, ER stress, IRE1, UPR, yeast cell death
Citation: Austriaco N (2012) Endoplasmic reticulum involvement in yeast cell death. Front. Oncol. 2:87. doi: 10.3389/fonc.2012.00087
Received: 05 May 2012; Paper pending published: 31 May 2012;
Accepted: 17 July 2012; Published online: 02 August 2012.
Edited by:Manuela Côrte-Real, Universidade do Minho, Portugal
Reviewed by:Campbell Gourlay, University of Kent, UK
Copyright: © 2012 Austriaco. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics, etc.
*Correspondence: Nicanor Austriaco, Department of Biology, Providence College, 1 Cunningham Square, Providence, RI 02918, USA. e-mail: email@example.com