Radiation-induced alterations in histone modification patterns and their potential impact on short-term radiation effects
- 1Department of Radiation Oncology, Ludwig-Maximilians-University, Munich, Germany
- 2Clinical Cooperation Group Osteosarcoma, Helmholtz Zentrum München–National Research Center for Environmental Health, Neuherberg, Germany
- 3Department of Pediatrics, Technical University Munich and Pediatric Oncology Center, Munich, Germany
Detection and repair of radiation-induced DNA damage occur in the context of chromatin. An intricate network of mechanisms defines chromatin structure, including DNA methylation, incorporation of histone variants, histone modifications, and chromatin remodeling. In the last years it became clear that the cellular response to radiation-induced DNA damage involves all of these mechanisms. Here we focus on the current knowledge on radiation-induced alterations in post-translational histone modification patterns and their effect on the chromatin accessibility, transcriptional regulation and chromosomal stability.
Keywords: post-translational histone modifications, radiation, double-strand breaks, DNA damage response, chromatin
Citation: Friedl AA, Mazurek B and Seiler DM (2012) Radiation-induced alterations in histone modification patterns and their potential impact on short-term radiation effects. Front. Oncol. 2:117. doi: 10.3389/fonc.2012.00117
Received: 10 August 2012; Paper pending published: 21 August 2012;
Accepted: 28 August 2012; Published online: 19 September 2012.
Edited by:Gabriele Multhoff, Klinikum Rechts der Isar Technische Universität München, Germany
Reviewed by:Franz Rödel, Johann Wolfgang Goethe-University Frankfurt am Main, Germany
Thomas E. Schmid, Klinikum Rechts der Isar Technische Universitaet Muenchen, Germany
Copyright © 2012 Friedl, Mazurek and Seiler. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
*Correspondence: Anna A. Friedl, Department of Radiation Oncology, Ludwig-Maximilians-University Munich, Schillerstr. 42, 80339 Munich, Germany. e-mail: firstname.lastname@example.org