%A Radunskaya,Ami %A de Pillis,Lisette %A Gallegos,Angela %D 2013 %J Frontiers in Oncology %C %F %G English %K mathematical model,Cancer,Immunotherapy,Melanoma,Dendritic Cell Vaccine %Q %R 10.3389/fonc.2013.00056 %W %L %M %P %7 %8 2013-March-19 %9 Original Research %+ Prof Ami Radunskaya,Pomona College, Claremont Colleges,Mathematics,610 N. College Ave.,Claremont,91711,CA,United States,aradunskaya@pomona.edu %# %! A Model of Dendritic Cell Therapy for Melanoma %* %< %T A Model of Dendritic Cell Therapy for Melanoma %U https://www.frontiersin.org/articles/10.3389/fonc.2013.00056 %V 3 %0 JOURNAL ARTICLE %@ 2234-943X %X Dendritic cells are a promising immunotherapy tool for boosting an individual’s antigen-specific immune response to cancer. We develop a mathematical model using differential and delay-differential equations to describe the interactions between dendritic cells, effector-immune cells, and tumor cells. We account for the trafficking of immune cells between lymph, blood, and tumor compartments. Our model reflects experimental results both for dendritic cell trafficking and for immune suppression of tumor growth in mice. In addition, in silico experiments suggest more effective immunotherapy treatment protocols can be achieved by modifying dose location and schedule. A sensitivity analysis of the model reveals which patient-specific parameters have the greatest impact on treatment efficacy.