Original Research ARTICLE

Front. Oncol., 20 March 2013 | http://dx.doi.org/10.3389/fonc.2013.00057

A decade in banking Ewing sarcoma: a report from the Children’s Oncology Group

Scott C. Borinstein1*, Natalie Beeler2, John J. Block3, Richard Gorlick4, Patrick Grohar1, Paul Jedlicka5, Mark Krailo6, Carol Morris7, Sharon Phillips8, Gene P. Siegal9, Elizabeth R. Lawlor10, Stephen L. Lessnick11 and COG Ewing Sarcoma Biology Committee
  • 1Division of Pediatric Hematology/Oncology, Department of Pediatrics, Vanderbilt University, Nashville, TN, USA
  • 2Children’s Oncology Group, Biopathology Center, Columbus, OH, USA
  • 3Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA
  • 4Division of Pediatric Hematology/Oncology, Department of Pediatrics, Montefiore Medical Center, New York, NY, USA
  • 5Department of Pathology, Children’s Hospital Colorado, Anschutz Medical Campus, University of Colorado Denver, Aurora, CO, USA
  • 6Department of Statistics, Children’s Oncology Group, Monrovia, CA, USA
  • 7Department of Orthopedic Surgery, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY, USA
  • 8Department of Biostatistics, Vanderbilt University, Nashville, TN, USA
  • 9Department of Pathology, UAB and the UAB Comprehensive Cancer Center, University of Alabama, Birmingham, AL, USA
  • 10Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of Michigan, Arbor, MI, USA
  • 11Division of Pediatric Hematology/Oncology, Department of Oncological Sciences, The Center for Children’s Cancer Research, Huntsman Cancer Institute, Salt Lake City, UT, USA

Outcomes for patients with metastatic and recurrent Ewing sarcoma remain poor and a better understanding of the biology of this malignancy is critical to the development of prognostic biomarkers and novel therapies. Therefore, the Children’s Oncology Group (COG) has created tissue banking protocols designed to collect high quality, clinically annotated, tumor specimens that can be distributed to researchers to perform basic science and correlative investigation. Data from the COG Ewing sarcoma tissue banking protocols AEWS02B1 and its successor study AEWS07B1 were reviewed in this study. Six-hundred and thirty five patients were enrolled on AEWS02B1 and 396 patients have had tissue submitted to AEWS07B1. The average age of participation was 13.2 years. About 86% were less than 19 years old and only 6% were greater than 21 years of age at diagnosis. When compared to SEER data, approximately 18% of all cases and only 8% of all patients >20 years old diagnosed with Ewing sarcoma annually in the United States have had tumor banked. The majority of participants submitted formalin fixed, paraffin embedded, primary tumor and blood samples. In total, fresh frozen tissue was submitted for only 29% of cases. Only seven metastatic tumor samples have been collected. Although the COG has been successful in collecting tumor samples from patients newly diagnosed with Ewing sarcoma, fresh frozen tumor specimens from primary and metastatic disease are critically needed, especially from young adult patients, in order to conduct high quality basic science and translational research investigation with a goal of developing better treatments.

Keywords: Ewing sarcoma, tumor banking, biopsy, interventional radiology, bone tumor, adolescent and young adult

Citation: Borinstein SC, Beeler N, Block JJ, Gorlick R, Grohar P, Jedlicka P, Krailo M, Morris C, Phillips S, Siegal GP, Lawlor ER, Lessnick SL and COG Ewing Sarcoma Biology Committee (2013) A decade in banking Ewing sarcoma: a report from the Children’s Oncology Group. Front. Oncol. 3:57. doi: 10.3389/fonc.2013.00057

Received: 18 January 2013; Paper pending published: 10 February 2013;
Accepted: 03 March 2013; Published online: 20 March 2013.

Edited by:

Douglas Hawkins, Seattle Children’s Hospital, USA

Reviewed by:

Meredith Irwin, Hospital for Sick Children, Canada
Carola Arndt, Mayo Clinic, USA

Copyright: © 2013 Borinstein, Beeler, Block, Gorlick, Grohar, Jedlicka, Krailo, Morris, Phillips, Siegal, Lawlor, Lessnick and COG Ewing Sarcoma Biology Committee. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Scott C. Borinstein, Division of Pediatric Hematology/Oncology, Vanderbilt University, 390 PRB, 2200 Pierce Avenue, Nashville, TN 37232-6310, USA. e-mail: scott.c.borinstein@vanderbilt.edu