Original Research ARTICLE

Front. Oncol., 11 July 2013 | http://dx.doi.org/10.3389/fonc.2013.00182

Molecular characteristics in MRI-classified group 1 glioblastoma multiforme

  • 1Department of Chemistry, University of Texas at San Antonio, San Antonio, TX, USA
  • 2Department of Biology, University of Texas at San Antonio, San Antonio, TX, USA
  • 3Department of Cancer Biology and Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
  • 4Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA, USA
  • 5Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California at San Francisco, San Francisco, CA, USA
  • 6Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, DC, USA
  • 7Neuroscience Institute, University of Texas at San Antonio, San Antonio, TX, USA

Glioblastoma multiforme (GBM) is a clinically and pathologically heterogeneous brain tumor. Previous studies of transcriptional profiling have revealed biologically relevant GBM subtypes associated with specific mutations and dysregulated pathways. Here, we applied a modified proteome to uncover abnormal protein expression profile in a MRI-classified group I GBM (GBM1), which has a spatial relationship with one of the adult neural stem cell niches, subventricular zone (SVZ). Most importantly, we identified molecular characteristics in this type of GBM that include up-regulation of metabolic enzymes, ribosomal proteins, and heat shock proteins. As GBM1 often recurs at great distances from the initial lesion, the rewiring of metabolism, and ribosomal biogenesis may facilitate cancer cells’ growth and survival during tumor progression. The intimate contact between GBM1 and the SVZ raises the possibility that tumor cells in GBM1 may be most related to SVZ cells. In support of this notion, we found that markers representing SVZ cells are highly expressed in GBM1. Emerged findings from our study provide a specific protein expression profile in GBM1 and offer better prediction or therapeutic implication for this multifocal GBM.

Keywords: SVZ, GBM, ribogenesis, heat shock protein, oncoprotein

Citation: Haskins WE, Zablotsky BL, Foret MR, Ihrie RA, Alvarez-Buylla A, Eisenman RN, Berger MS and Lin C-HA (2013) Molecular characteristics in MRI-classified group 1 glioblastoma multiforme. Front. Oncol. 3:182. doi: 10.3389/fonc.2013.00182

Received: 25 April 2013; Accepted: 27 June 2013;
Published online: 11 July 2013.

Edited by:

Ann Bode, The Hormel Institute University of Minnesota and Mayo Clinic, USA

Reviewed by:

Giorgio Stassi, University of Palermo, Italy
Min Hee Kang, Texas Tech University Health Sciences Center School of Medicine, USA

Copyright: © 2013 Haskins, Zablotsky, Foret, Ihrie, Alvarez-Buylla, Eisenman, Berger and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Chin-Hsing Annie Lin, Department of Biology, University of Texas at San Antonio, One UTSA Circle, BSB 2.03.24, San Antonio, TX 78249, USA e-mail: annie.lin@utsa.edu

Bethany L. Zablotsky and Michael R. Foret have contributed equally to this work.