TY - JOUR AU - Rimessi, Alessandro AU - Patergnani, Simone AU - Ioannidi, Elli AU - Pinton, Paolo PY - 2013 M3 - Mini Review TI - Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ JO - Frontiers in Oncology UR - https://www.frontiersin.org/articles/10.3389/fonc.2013.00232 VL - 3 SN - 2234-943X N2 - Atypical protein kinase C isoforms are serine threonine kinases involved in various pathological conditions. In recent years, the PKCζ isoform has emerged as an important regulator of multiple cellular processes operating in cancer. In this review, we will focus on the PKCζ isoform as an oxidative-sensing kinase involved in cancer-related inflammation and chemoresistance. We will discuss its nuclear localization and its possible pivotal role in connecting inflammation with drug resistance. ER -