%A Hernandez,Brenda %A Goodman,Marc %A Unger,Elizabeth %A Steinau,Martin %A Powers,Amy %A Lynch,Charles %A Cozen,Wendy %A Saber,Maria %A Peters,Edward %A Wilkinson,Edward %A Copeland,Glenn %A Hopenhayn,Claudia %A Huang,Youjie %A Watson,Meg %A Altekruse,Sean %A Lyu,Christopher %A Saraiya,Mona %D 2014 %J Frontiers in Oncology %C %F %G English %K Human papillomavirus,HPV,Prevalence,Penile Cancer,United States %Q %R 10.3389/fonc.2014.00009 %W %L %M %P %7 %8 2014-February-05 %9 Original Research %+ Dr Brenda Hernandez,University of Hawaii Cancer Center,701 Ilalo Street,Honolulu,96813,Hawaii,United States,brenda@cc.hawaii.edu %# %! HPV in penile cancers %* %< %T Human papillomavirus genotype prevalence in invasive penile cancers from a registry-based United States population %U https://www.frontiersin.org/articles/10.3389/fonc.2014.00009 %V 4 %0 JOURNAL ARTICLE %@ 2234-943X %X Background: Human papillomavirus (HPV) is estimated to play an etiologic role in 40–50% of penile cancers worldwide. Estimates of HPV prevalence in U.S. penile cancer cases are limited.Methods: HPV DNA was evaluated in tumor tissue from 79 invasive penile cancer patients diagnosed in 1998–2005 within the catchment areas of seven U.S. cancer registries. HPV was genotyped using PCR-based Linear Array and INNO-LiPA assays and compared by demographic, clinical, and pathologic characteristics and survival. Histological classification was also obtained by independent pathology review.Results: HPV DNA was present in 50 of 79 (63%) of invasive penile cancer cases. Sixteen viral genotypes were detected. HPV 16, found in 46% (36/79) of all cases (72% of HPV-positive cases) was the most prevalent genotype followed equally by HPV 18, 33, and 45, each of which comprised 5% of all cases. Multiple genotypes were detected in 18% of viral positive cases. HPV prevalence did not significantly vary by age, race/ethnicity, population size of geographic region, cancer stage, histology, grade, penile subsite, or prior cancer history. Penile cases diagnosed in more recent years were more likely to be HPV-positive. Overall survival did not significantly vary by HPV status.Conclusion: The relatively high prevalence of HPV in our study population provides limited evidence of a more prominent and, possibly, increasing role of infection in penile carcinogenesis in the U.S. compared to other parts of the world.