3.8
Impact Factor

Review ARTICLE

Front. Pharmacol., 25 February 2011 | http://dx.doi.org/10.3389/fphar.2011.00010

Anti-inflammatory and immunomodulatory effects of Paeonia lactiflora Pall., a traditional Chinese herbal medicine

Dong-Yi He1 and Sheng-Ming Dai2*
  • 1 Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai, China
  • 2 Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, Shanghai, China

In China, Korea, and Japan, a decoction of the dried root without bark of Paeonia lactiflora Pall. has been used in the treatment of rheumatoid arthritis, systemic lupus erythematosus, hepatitis, dysmenorrhea, muscle cramping and spasms, and fever for more than 1200 years. A water/ethanol extract of the root is now known as total glucosides of peony (TGP), which contains more than 15 components. Paeoniflorin is the most abundant ingredient and accounts for the pharmacological effects observed with TGP in both in vitro and in vivo studies. The analgesic effect of TGP was confirmed in various animal models of pain, which may be mediated partly by adenosine A1 receptor. The direct anti-inflammatory effects of TGP were observed in animal models of both acute and subacute inflammation, by inhibiting the production of prostaglandin E2, leukotriene B4, and nitric oxide, and by suppressing the increase of intracellular calcium ion concentration. TGP was also reported to have protective effects of cells against oxidative stress. In vitro, dual effects of TGP were noted on the proliferation of lymphocytes, differentiation of Th/Ts lymphocytes, and the production of proinflammatory cytokines and antibodies. In vivo, TGP inhibited the delayed-type hypersensitivity in immuno-activated mice, and enhanced the delayed-type hypersensitivity in immuno-suppressed mice. In adjuvant arthritis rats, paeoniflorin exerted immunosuppressive effects. The beneficial effects of TGP in treating rheumatoid arthritis were verified by randomized controlled trials. The adverse events of TGP were mainly gastrointestinal tract disturbances, mostly mild diarrhea.

Keywords: Paeoniae Radix, anti-inflammation, immunomodulation, Chinese herbal medicine

Citation: He D-Y and Dai S-M (2011) Anti-inflammatory and immunomodulatory effects of Paeonia lactiflora Pall., a traditional Chinese herbal medicine. Front. Pharmacol. 2:10. doi: 10.3389/fphar.2011.00010

Received: 28 December 2010; Accepted: 14 February 2011;
Published online: 25 February 2011.

Edited by:

Yili Yang, Second Military Medical University, China

Reviewed by:

Yili Yang, Second Military Medical University, China
Genbin Shi, National Cancer institute, USA

Copyright: © 2011 He and Dai. This is an open-access article subject to an exclusive license agreement between the authors and Frontiers Media SA, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

*Correspondence: Sheng-Ming Dai, Department of Rheumatology and Immunology, Changhai Hospital, Second Military Medical University, 174 Changhai Road, Shanghai 200433, China. e-mail: dsm@medmail.com.cn