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Front. Pharmacol., 17 July 2012 | http://dx.doi.org/10.3389/fphar.2012.00141

Resveratrol: French paradox revisited

Betul Catalgol, Saime Batirel, Yavuz Taga and Nesrin Kartal Ozer*
  • Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center, Marmara University, Istanbul, Turkey

Resveratrol is a polyphenol that plays a potentially important role in many disorders and has been studied in different diseases. The research on this chemical started through the “French paradox,” which describes improved cardiovascular outcomes despite a high-fat diet in French people. Since then, resveratrol has been broadly studied and shown to have antioxidant, anti-inflammatory, anti-proliferative, and anti-angiogenic effects, with those on oxidative stress possibly being most important and underlying some of the others, but many signaling pathways are among the molecular targets of resveratrol. In concert they may be beneficial in many disorders, particularly in diseases where oxidative stress plays an important role. The main focus of this review will be the pathways affected by resveratrol. Based on these mechanistic considerations, the involvement of resveratrol especially in cardiovascular diseases, cancer, neurodegenerative diseases, and possibly in longevity will be is addressed.

Keywords: cancer, cardiovascular diseases, resveratrol, signal transduction

Citation: Catalgol B, Batirel S, Taga Y and Ozer NK (2012) Resveratrol: French paradox revisited. Front. Pharmacol. 3:141. doi: 10.3389/fphar.2012.00141

Received: 08 February 2012; Accepted: 27 June 2012;
Published online: 17 July 2012.

Edited by:

Issy Laher, University of British Columbia, Canada

Reviewed by:

Ramaroson Andriantsitoaina, Université d’Angers, France
Huige Li, Johannes Gutenberg University Mainz, Germany
Valérie Schini-Kerth, University of Strasbourg, France

Copyright: © 2012 Catalgol, Batirel, Taga and Ozer. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Nesrin Kartal Ozer, Department of Biochemistry, Faculty of Medicine, Genetic and Metabolic Diseases Research Center, Marmara University, 34668 Haydarpasa, Istanbul, Turkey. e-mail: nkozer@marmara.edu.tr