@ARTICLE{10.3389/fphar.2016.00396, AUTHOR={Böhm, Ruwen and Cascorbi, Ingolf}, TITLE={Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions}, JOURNAL={Frontiers in Pharmacology}, VOLUME={7}, YEAR={2016}, URL={https://www.frontiersin.org/articles/10.3389/fphar.2016.00396}, DOI={10.3389/fphar.2016.00396}, ISSN={1663-9812}, ABSTRACT={Adverse drug reactions adverse drug reaction (ADR) occur in approximately 17% of patients. Avoiding ADR is thus mandatory from both an ethical and an economic point of view. Whereas, pharmacogenetics changes of the pharmacokinetics may contribute to the explanation of some type A reactions, strong relationships of genetic markers has also been shown for drug hypersensitivity belonging to type B reactions. We present the classifications of ADR, discuss genetic influences and focus on delayed-onset hypersensitivity reactions, i.e., drug-induced liver injury, drug-induced agranulocytosis, and severe cutaneous ADR. A guidance how to read and interpret the contingency table is provided as well as an algorithm whether and how a test for a pharmacogenetic biomarker should be conducted.} }