Review ARTICLE

Front. Physiol., 18 May 2012 | doi: 10.3389/fphys.2012.00143

Function and regulation of lipid biology in Caenorhabditis elegans aging

Nicole Shangming Hou1,2,3 and Stefan Taubert1,2,3,4*
  • 1 Graduate Program in Cell and Developmental Biology, University of British Columbia, Vancouver, BC, Canada
  • 2 Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada
  • 3 Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
  • 4 Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada

Rapidly expanding aging populations and a concomitant increase in the prevalence of age-related diseases are global health problems today. Over the past three decades, a large body of work has led to the identification of genes and regulatory networks that affect longevity and health span, often benefiting from the tremendous power of genetics in vertebrate and invertebrate model organisms. Interestingly, many of these factors appear linked to lipids, important molecules that participate in cellular signaling, energy metabolism, and structural compartmentalization. Despite the putative link between lipids and longevity, the role of lipids in aging remains poorly understood. Emerging data from the model organism Caenorhabditis elegans suggest that lipid composition may change during aging, as several pathways that influence aging also regulate lipid metabolism enzymes; moreover, some of these enzymes apparently play key roles in the pathways that affect the rate of aging. By understanding how lipid biology is regulated during C. elegans aging, and how it impacts molecular, cellular, and organismal function, we may gain insight into novel ways to delay aging using genetic or pharmacological interventions. In the present review we discuss recent insights into the roles of lipids in C. elegans aging, including regulatory roles played by lipids themselves, the regulation of lipid metabolic enzymes, and the roles of lipid metabolism genes in the pathways that affect aging.

Keywords: C. elegans, lipids, lipase, ascarosides, fatty acids, nuclear hormone receptors, mitochondria, N-acylethanolamine

Citation: Hou NS and Taubert S (2012) Function and regulation of lipid biology in Caenorhabditis elegans aging. Front. Physio. 3:143. doi: 10.3389/fphys.2012.00143

Received: 05 April 2012; Paper pending published: 26 April 2012;
Accepted: 27 April 2012; Published online: 18 May 2012.

Edited by:

Vladimir Titorenko, Concordia University, Canada

Reviewed by:

Christy Carter, University of Florida, USA
Luciana Campos, University Camilo Castelo Branco, Brazil

Copyright: © 2012 Hou and Taubert. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

*Correspondence: Stefan Taubert, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Room 3018, 950 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4. e-mail: taubert@cmmt.ubc.ca

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