Endothelin-1 (ET-1) is a peptide signaling molecule serving diverse functions in many different tissues such as the vasculature and the kidney. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (EDN1), but recent research suggests that EDN1 expression is attenuated by microRNA (miRNA)—mediated regulation. The action of specific miRNAs on EDN1 mRNA appears to vary greatly in a tissue specific manner. This review provides a summary of our current understanding of miRNA-EDN1 interaction.
Keywords: microRNA, endothelin-1, endothelin signaling, EDN1 mRNA, ET-1
Citation: Jacobs ME, Wingo CS and Cain BD (2013) An emerging role for microRNA in the regulation of endothelin-1. Front. Physio. 4:22. doi: 10.3389/fphys.2013.00022
Received: 15 January 2013; Accepted: 28 January 2013;
Published online: 19 February 2013.
Edited by:James D. Stockand, University of Texas Health Science Center at San Antonio, USA
Reviewed by:Robert S. Edinger, University of Pittsburgh, USA
Copyright © 2013 Jacobs, Wingo and Cain. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
*Correspondence: Brian D. Cain, Department of Biochemistry and Molecular Biology, University of Florida, PO Box 100245, Gainesville, FL 32610, USA. e-mail: email@example.com