%A Jacobs,Mollie %A Wingo,Charles %A Cain,Brian %D 2013 %J Frontiers in Physiology %C %F %G English %K microRNA,Endothelin-1,Endothelin signaling,EDN1 mRNA,ET-1 %Q %R 10.3389/fphys.2013.00022 %W %L %M %P %7 %8 2013-February-19 %9 Mini Review %+ Dr Brian Cain,University of Florida,Biochemistry and Molecular Biology,1200 Newell DR,R3-234/ARB,Gainesville,32610,FL,United States,bcain@ufl.edu %# %! miRNA regulation of ET-1 expression %* %< %T An emerging role for microRNA in the regulation of endothelin-1 %U https://www.frontiersin.org/articles/10.3389/fphys.2013.00022 %V 4 %0 JOURNAL ARTICLE %@ 1664-042X %X Endothelin-1 (ET-1) is a peptide signaling molecule serving diverse functions in many different tissues such as the vasculature and the kidney. The primary mechanism thought to control ET-1 bioavailability is the rate of transcription from the ET-1 gene (EDN1), but recent research suggests that EDN1 expression is attenuated by microRNA (miRNA)—mediated regulation. The action of specific miRNAs on EDN1 mRNA appears to vary greatly in a tissue specific manner. This review provides a summary of our current understanding of miRNA-EDN1 interaction.