This article is part of the Research Topic Second hand smoke and COPD: lessons from animal studies


Front. Physiol., 27 February 2013 | doi: 10.3389/fphys.2013.00030

Second hand smoke and COPD: lessons from animal studies

  • Department of Medicine, Columbia University, New York, NY, USA

Exposure to second hand smoke is a major cause of chronic obstructive pulmonary disease (COPD) in the non-smoker. In this review we explore the use of animal smoke exposure models and their insight into disease pathogenesis. The methods of smoke exposure, including exposure delivery systems, are described. Key findings from the acute and chronic smoke exposure models are outlined, including descriptions of the inflammation processes, proteases involved, oxidative stress, and apoptosis. Finally, alternatives to rodent models of lung disease are presented.

Keywords: emphysema, COPD, animal models, cigarette smoke, inflammation, apoptosis, proteases

Citation: Goldklang MP, Marks SM and D'Armiento JM (2013) Second hand smoke and COPD: lessons from animal studies. Front. Physiol. 4:30. doi: 10.3389/fphys.2013.00030

Received: 24 November 2012; Paper pending published: 08 January 2013;
Accepted: 07 February 2013; Published online: 27 February 2013.

Edited by:

Laima Taraseviciene-Stewart, University of Colorado Denver, USA

Reviewed by:

Jana Plevkova, Commenius University, Slovakia
Sarah Miller, University of Memphis, USA

Copyright © 2013 Goldklang, Marks and D'Armiento. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Jeanine M. D'Armiento, Department of Medicine, Division of Molecular Medicine, Columbia University, 630 West 168th Street, P&S 9-449, New York, NY 10032, USA. e-mail:

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