Pancreatic cancer is highly chemoresistant. A major contributing factor is the characteristic extensive stromal or fibrotic reaction, which comprises up to 90% of the tumor volume. Over the last decade there has been intensive research into the role of the pro-fibrogenic pancreatic stellate cells (PSCs) and their interaction with pancreatic cancer cells. As a result of the significant alterations in the tumor microenvironment following activation of PSCs, tumor progression, and chemoresistance is enhanced. This review will discuss how PSCs contribute to chemoresistance in pancreatic cancer.
Keywords: pancreatic cancer, chemoresistance, pancreatic stellate cells, stroma, fibrosis, hypoxia
Citation: McCarroll JA, Naim S, Sharbeen G, Russia N, Lee J, Kavallaris M, Goldstein D and Phillips PA (2014) Role of pancreatic stellate cells in chemoresistance in pancreatic cancer. Front. Physiol. 5:141. doi: 10.3389/fphys.2014.00141
Received: 12 February 2014; Paper pending published: 27 February 2014;
Accepted: 24 March 2014; Published online: 09 April 2014.
Edited by:Atsushi Masamune, Tohoku University Graduate School of Medicine, Japan
Reviewed by:Kyoko Shimizu, Tokyo Women's Medical University, Japan
Copyright © 2014 McCarroll, Naim, Sharbeen, Russia, Lee, Kavallaris, Goldstein and Phillips. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Phoebe A. Phillips, Pancreatic Cancer Translational Research Group, Lowy Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, High St., Randwick, Sydney, NSW 2052, Australia e-mail: email@example.com
†These authors have contributed equally to this work.