Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells that further propagate atherosclerotic inflammation. Regulatory T cells (Tregs) can suppress proinflammatory function of mature DCs. In contrast, immature DCs are able to induce Tregs and prevent differentiation of naïve T cells to proinflammatory effector T cells by initiating apoptosis and anergy in naïve T cells. Indeed, immature DCs showed tolerogenic and anti-inflammatory properties. Thus, DCs play a double role in atherosclerosis: mature DCs are proatherogenic while immature DCs appear to be anti-atherogenic. Tolerogenic and anti-inflammatory capacity of immature DCs can be therefore utilized for the development of new immunotherapeutic strategies against atherosclerosis.
Keywords: atherosclerosis, atherogenesis, inflammation, immune reactions, dendritic cells, arteries
Citation: Chistiakov DA, Sobenin IA, Orekhov AN and Bobryshev YV (2014) Dendritic cells in atherosclerotic inflammation: the complexity of functions and the peculiarities of pathophysiological effects. Front. Physiol. 5:196. doi: 10.3389/fphys.2014.00196
Received: 12 February 2014; Accepted: 09 May 2014;
Published online: 27 May 2014.
Edited by:Mariappan Muthuchamy, Texas A&M Health Science Center, USA
Reviewed by:Sanjukta Chakraborty, Texas A&M Health Science Center, USA
Copyright © 2014 Chistiakov, Sobenin, Orekhov and Bobryshev. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yuri V. Bobryshev, Faculty of Medicine, University of New South Wales, High Street UNSW, Sydney, NSW 2052, Australia e-mail: firstname.lastname@example.org