Mini Review ARTICLE

Front. Physiol., 28 May 2014 | doi: 10.3389/fphys.2014.00197

MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?

  • Biological Sciences Research Group, Department of Bioengineering, Instituto Superior Técnico, IBB - Institute for Biotechnology and Bioengineering, Universidade de Lisboa, Lisbon, Portugal

Infections caused by opportunistic fungal pathogens have reached concerning numbers due to the increase of the immunocrompromised human population and to the development of antifungal resistance. This resistance is often attributed to the action of multidrug efflux pumps, belonging to the ATP-binding cassette (ABC) superfamily and the major facilitator superfamily (MFS). Although many studies have focused on the role of ABC multidrug efflux transporters, little is still known on the part played by the Drug:H+ Antiporter (DHA) family of the MFS in this context. This review summarizes current knowledge on the role in antifungal drug resistance, mode of action and phylogenetic relations of DHA transporters, from the model yeast S. cerevisiae to pathogenic yeasts and filamentous fungi. Through the compilation of the predicted DHA transporters in the medically relevant Candida albicans, C. glabrata, C. parapsilosis, C. lusitaniae, C. tropicalis, C. guilliermondii, Cryptococcus neoformans, and Aspergillus fumigatus species, the fact that only 5% of the DHA transporters from these organisms have been characterized so far is evidenced. The role of these transporters in antifungal drug resistance and in pathogen-host interaction is described and their clinical relevance discussed. Given the knowledge gathered for these few DHA transporters, the need to carry out a systematic characterization of the DHA multidrug efflux pumps in fungal pathogens, with emphasis on their clinical relevance, is highlighted.

Keywords: multidrug resistance efflux pumps, drug:H+ antiporters, antifungal drug resistance, pathogenic fungi, Candida species

Citation: Costa C, Dias PJ, Sá-Correia I and Teixeira MC (2014) MFS multidrug transporters in pathogenic fungi: do they have real clinical impact? Front. Physiol. 5:197. doi: 10.3389/fphys.2014.00197

Received: 26 March 2014; Accepted: 09 May 2014;
Published online: 28 May 2014.

Edited by:

Paula Duque, Instituto Gulbenkian de Ciência, Portugal

Reviewed by:

Dominique Sanglard, University of Lausanne and University Hospital Center, Switzerland
Frederic Devaux, Universite Pierre et Marie Curie, France

Copyright © 2014 Costa, Dias, Sá-Correia and Teixeira. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Miguel C. Teixeira, Biological Sciences Research Group, Centro de Engenharia Biológica e Química, Instituto Superior Técnico, IBB - Institute for Biotechnology and Bioengineering, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal e-mail: mnpct@ist.utl.pt

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