AUTHOR=Goldman Alyssa, Burmeister Yvonne, Cesnulevicius Konstantin, Herbert Martha, Kane Mary, Lescheid David, McCaffrey Timothy, Schultz Myron, Seilheimer Bernd, Smit Alta, St. Laurent Georges, Berman Brian TITLE=Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity? JOURNAL=Frontiers in Physiology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/articles/10.3389/fphys.2015.00225 DOI=10.3389/fphys.2015.00225 ISSN=1664-042X ABSTRACT=Bioregulatory systems medicine (BrSM) is a paradigm that aims to advance current medical practices. The basic scientific and clinical tenets of this approach embrace an interconnected picture of human health, supported largely by recent advances in systems biology and genomics, and focus on the implications of multi-scale interconnectivity for improving therapeutic approaches to disease. This article introduces the formal incorporation of these scientific and clinical elements into a cohesive theoretical model of the BrSM approach. The authors review this integrated body of knowledge and discuss how the emergent conceptual model offers the medical field a new avenue for extending the armamentarium of current treatment and healthcare, with the ultimate goal of improving population health.