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This article is part of the Research Topic Current challenges in plant cell walls

Mini Review ARTICLE

Front. Plant Sci., 03 May 2012 | http://dx.doi.org/10.3389/fpls.2012.00084

Deciphering the molecular functions of sterols in cellulose biosynthesis

Kathrin Schrick1*, Seth DeBolt2 and Vincent Bulone3
  • 1 Division of Biology, Kansas State University, Manhattan, KS, USA
  • 2 Department of Horticulture, University of Kentucky, Lexington, KY, USA
  • 3 Division of Glycoscience, Royal Institute of Technology, School of Biotechnology, AlbaNova University Centre, Stockholm, Sweden

Sterols play vital roles in plant growth and development, as components of membranes and as precursors to steroid hormones. Analysis of Arabidopsis mutants indicates that sterol composition is crucial for cellulose biosynthesis. Sterols are widespread in the plasma membrane (PM), suggesting a possible link between sterols and the multimeric cellulose synthase complex. In one possible scenario, molecular interactions in sterol-rich PM microdomains or another form of sterol-dependent membrane scaffolding may be critical for maintaining the correct subcellular localization, structural integrity and/or activity of the cellulose synthase machinery. Another possible link may be through steryl glucosides, which could act as primers for the attachment of glucose monomers during the synthesis of β−(1 → 4) glucan chains that form the cellulose microfibrils. This mini-review examines genetic and biochemical data supporting the link between sterols and cellulose biosynthesis in cell wall formation and explores potential approaches to elucidate the mechanism of this association.

Keywords: sterols, steryl glucosides, cellulose, plasma membrane microdomains, lipid rafts, cell wall

Citation: Schrick K, DeBolt S and Bulone V (2012) Deciphering the molecular functions of sterols in cellulose biosynthesis. Front. Plant Sci. 3:84. doi: 10.3389/fpls.2012.00084

Received: 20 March 2012; Paper pending published: 02 April 2012;
Accepted: 15 April 2012; Published online: 03 May 2012.

Edited by:

Jose Manuel Estevez, University of Buenos Aires and CONICET, Argentina

Reviewed by:

Andrew Carroll, Stanford University, USA
Charles T. Anderson, The Pennsylvania State University, USA

Copyright: © 2012 Schrick, DeBolt and Bulone. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

*Correspondence: Kathrin Schrick, Division of Biology, Kansas State University, Ackert Hall 116, Manhattan, KS 66506, USA. e-mail: kschrick@ksu.edu