TY - JOUR AU - Melcher, Ulrich AU - Verma, Ruchi AU - Schneider, William L. PY - 2014 M3 - Mini Review TI - Metagenomic search strategies for interactions among plants and multiple microbes JO - Frontiers in Plant Science UR - https://www.frontiersin.org/articles/10.3389/fpls.2014.00268 VL - 5 SN - 1664-462X N2 - Plants harbor multiple microbes. Metagenomics can facilitate understanding of the significance, for the plant, of the microbes, and of the interactions among them. However, current approaches to metagenomic analysis of plants are computationally time consuming. Efforts to speed the discovery process include improvement of computational speed, condensing the sequencing reads into smaller datasets before BLAST searches, simplifying the target database of BLAST searches, and flipping the roles of metagenomic and reference datasets. The latter is exemplified by the e-probe diagnostic nucleic acid analysis approach originally devised for improving analysis during plant quarantine. ER -