@ARTICLE{10.3389/fpsyg.2011.00217, AUTHOR={Tsunada, Joji and Baker, Allison and Christison-Lagay, Kate and Davis, Selina and Cohen, Yale}, TITLE={Modulation of Cross-Frequency Coupling by Novel and Repeated Stimuli in the Primate Ventrolateral Prefrontal Cortex}, JOURNAL={Frontiers in Psychology}, VOLUME={2}, YEAR={2011}, URL={https://www.frontiersin.org/articles/10.3389/fpsyg.2011.00217}, DOI={10.3389/fpsyg.2011.00217}, ISSN={1664-1078}, ABSTRACT={Adaptive behavior depends on an animal’s ability to ignore uninformative stimuli, such as repeated presentations of the same stimulus, and, instead, detect informative, novel stimuli in its environment. The primate prefrontal cortex (PFC) is known to play a central role in this ability. However, the neural mechanisms underlying the ability to differentiate between repeated and novel stimuli are not clear. We hypothesized that the coupling between different frequency bands of the local field potential (LFP) underlies the PFC’s role in differentiating between repeated and novel stimuli. Specifically, we hypothesized that whereas the presentation of a novel-stimulus induces strong cross-frequency coupling, repeated presentations of the same stimulus attenuates this coupling. To test this hypothesis, we recorded LFPs from the ventrolateral PFC (vPFC) of rhesus monkeys while they listened to a novel vocalization and repeated presentations of the same vocalization. We found that the cross-frequency coupling between the gamma-band amplitude and theta-band phase of the LFP was modulated by repeated presentations of a stimulus. During the first (novel) presentation of a stimulus, gamma-band activity was modulated by the theta-band phase. However, with repeated presentations of the same stimulus, this cross-frequency coupling was attenuated. These results suggest that cross-frequency coupling may play a role in the neural computations that underlie the differentiation between novel and repeated stimuli in the vPFC.} }