%A Martín-María,Natalia %A Caballero,Francisco Félix %A Olaya,Beatriz %A Rodríguez-Artalejo,Fernando %A Haro,Josep Maria %A Miret,Marta %A Ayuso-Mateos,José Luis %D 2016 %J Frontiers in Psychology %C %F %G English %K experienced well-being,evaluative well-being,Mortality,Longitudinal Studies,Depression %Q %R 10.3389/fpsyg.2016.01040 %W %L %M %P %7 %8 2016-July-12 %9 Original Research %+ José Luis Ayuso-Mateos,Department of Psychiatry, School of Medicine, Universidad Autónoma de Madrid,Madrid, Spain,joseluis.ayuso@uam.es %+ José Luis Ayuso-Mateos,Department of Psychiatry, Instituto de Investigación Sanitaria Princesa, Hospital Universitario de La Princesa,Madrid, Spain,joseluis.ayuso@uam.es %+ José Luis Ayuso-Mateos,CIBER of Mental Health,Madrid, Spain,joseluis.ayuso@uam.es %# %! Positive affect is inversely associated with mortality %* %< %T Positive Affect Is Inversely Associated with Mortality in Individuals without Depression %U https://www.frontiersin.org/articles/10.3389/fpsyg.2016.01040 %V 7 %0 JOURNAL ARTICLE %@ 1664-1078 %X Background: Some studies have analyzed the relation between well-being and mortality but none of them have attempted to disentangle the differential influence that positive affect, negative affect, and evaluative well-being might have on mortality using a longitudinal design in the general population and measuring independently and accurately each component of well-being. The aim of the present study is to assess the association of these well-being components with mortality after adjusting for health and other lifestyle factors and to analyze whether this association is different in people with and without depression.Methods: A nationally representative sample of 4753 people from Spain was followed up after 3 years. Analyses were performed with Cox regression models among the total sample and separately in people with and without depression.Results: In the analyses adjusted for age, sex, and years of education, all three well-being variables showed separately a statistically significant association with mortality. However, after adjustment for health status and other confounders including the other well-being components, only positive affect remained as marginally associated with a decreased risk of mortality in the overall sample [HR = 0.87; 95% CI = 0.73–1.03], in particular among individuals without depression [HR = 0.82; 95% CI = 0.68–0.99].Conclusion: Positive affect is inversely associated with mortality in individuals without depression. Future research should focus on assessing interventions associated with a higher level of positive affect.