%A Casado,Javier G. %A Blázquez,Rebeca %A Vela,Francisco Javier %A Álvarez,Verónica %A Tarazona,Raquel %A Sánchez-Margallo,Francisco Miguel %D 2017 %J Frontiers in Veterinary Science %C %F %G English %K Exosomes,Mesenchymal Stem Cells,Synovitis,Immunomodulation,Inflammation %Q %R 10.3389/fvets.2017.00039 %W %L %M %P %7 %8 2017-March-21 %9 Original Research %+ Rebeca Blázquez,Stem Cell Therapy Unit, “Jesús Usón” Minimally Invasive Surgery Centre,Spain,rblazquez@ccmijesususon.com %+ Rebeca Blázquez,CIBER de Enfermedades Cardiovasculares,Spain,rblazquez@ccmijesususon.com %# %! MSCs-derived exosomes for the treatment of antigen-induced synovitis %* %< %T Mesenchymal Stem Cell-Derived Exosomes: Immunomodulatory Evaluation in an Antigen-Induced Synovitis Porcine Model %U https://www.frontiersin.org/articles/10.3389/fvets.2017.00039 %V 4 %0 JOURNAL ARTICLE %@ 2297-1769 %X Synovitis is an inflammatory process associated with pain, disability, and discomfort, which is usually treated with anti-inflammatory drugs or biological agents. Mesenchymal stem cells (MSCs) have been also successfully used in the treatment of inflammatory-related diseases such as synovitis or arthritis. In the last years, the exosomes derived from MSCs have become a promising tool for the treatment of inflammatory-related diseases and their therapeutic effect is thought to be mediated (at least in part) by their immunomodulatory potential. In this work, we aimed to evaluate the anti-inflammatory effect of these exosomes in an antigen-induced synovitis animal model. To our knowledge, this is the first report where exosomes derived from MSCs have been evaluated in an animal model of synovitis. Our results demonstrated a decrease of synovial lymphocytes together with a downregulation of TNF-α transcripts in those exosome-treated joints. These results support the immunomodulatory effect of these exosomes and point out that they may represent a promising therapeutic option for the treatment of synovitis.