AUTHOR=Eichler Sabrina, Meier Jochen TITLE=E-I balance and human diseases - from molecules to networking JOURNAL=Frontiers in Molecular Neuroscience VOLUME=1 YEAR=2008 URL=https://www.frontiersin.org/articles/10.3389/neuro.02.002.2008 DOI=10.3389/neuro.02.002.2008 ISSN=1662-5099 ABSTRACT=Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation.