TY - JOUR AU - Briggs, Farran PY - 2010 M3 - Review TI - Organizing principles of cortical layer 6 JO - Frontiers in Neural Circuits UR - https://www.frontiersin.org/articles/10.3389/neuro.04.003.2010 VL - 4 SN - 1662-5110 N2 - Neurons in the deepest layer of mammalian cerebral cortex are morphologically and physiological diverse and are situated in a strategic position to modulate neuronal activity locally and in other structures. The variety of neuronal circuits within which layer 6 neurons participate differs across species and cortical regions. However even amidst this diversity, common organizational features emerge. Examination of the anatomical and physiological characteristics of different classes of layer 6 neuron, each specialized to participate in distinct circuits, provides insight into the functional contributions of layer 6 neurons toward cortical information processing. ER -