This article is part of the Research Topic The developing human brain

Original Research ARTICLE

Front. Hum. Neurosci., 24 November 2009 | doi: 10.3389/neuro.09.055.2009

BDNF genotype modulates resting functional connectivity in children

Department of Psychology, Stanford University, Stanford, CA, USA
Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA
A specific polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with alterations in brain anatomy and memory; its relevance to the functional connectivity of brain networks, however, is unclear. Given that altered hippocampal function and structure has been found in adults who carry the methionine (met) allele of the BDNF gene and the molecular studies elucidating the role of BDNF in neurogenesis and synapse formation, we examined the association between BDNF gene variants and neural resting connectivity in children and adolescents. We observed a reduction in hippocampal and parahippocampal to cortical connectivity in met-allele carriers within both default-mode and executive networks. In contrast, we observed increased connectivity to amygdala, insula and striatal regions in met-carriers, within the paralimbic network. Because of the known association between the BDNF gene and neuropsychiatric disorder, this latter finding of greater connectivity in circuits important for emotion processing may indicate a new neural mechanism through which these gene-related psychiatric differences are manifest. Here we show that the BDNF gene, known to regulate synaptic plasticity and connectivity in the brain, affects functional connectivity at the neural systems level. In addition, we demonstrate that the spatial topography of multiple high-level resting state networks in healthy children and adolescents is similar to that observed in adults.
fMRI, children, adolescents, resting-state, functional connectivity, BDNF, gene
Thomason ME, Yoo DJ, Glover GH and Gotlib IH (2009). BDNF genotype modulates resting functional connectivity in children. Front. Hum. Neurosci. 3:55. doi: 10.3389/neuro.09.055.2009
04 August 2009;
 Paper pending published:
28 August 2009;
06 November 2009;
 Published online:
24 November 2009.

Edited by:

Elizabeth D. O'Hare, University of California at Berkeley, USA

Reviewed by:

Damien Fair, Oregon Health and Science University, USA
Naftali Raz, Wayne State University, USA
© 2009 Thomason, Yoo, Glover and Gotlib. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Moriah E. Thomason, Department of Psychology, Stanford University, Jordan Hall, Bldg. 420, Stanford, CA 94305-2130, USA. e-mail:
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