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Front. Aging Neurosci., 12 February 2010 | http://dx.doi.org/10.3389/neuro.24.004.2010

KIBRA: a new gateway to learning and memory?

SYGNIS Bioscience, Heidelberg, Germany
The Translational Genomics Research Institute, Phoenix, AZ, USA
Department of Molecular Nephrology, University Hospital Münster, Münster, Germany
Amnestix Incorporated, Burlingame, CA, USA
The genetic locus encoding KIBRA, a member of the WWC family of proteins, has recently been shown to be associated with human memory performance through genome-wide single nucleotide polymorphism screening. Gene expression analysis and a variety of functional studies have further indicated that such a role is biologically plausible for KIBRA. Here, we review the existing literature, illustrate connections between the different lines of evidence, and derive models based on KIBRA’s function(s) in the brain that can be further tested experimentally.
cognition, memory, hippocampus, genome-wide association study (GWAS), Alzheimer’s disease, cognitive impairment, PKCζ
Schneider A, Huentelman MJ, Kremerskothen J, Duning K, Spoelgen R and Nikolich K (2010). KIBRA: a new gateway to learning and memory? Front. Ag. Neurosci. 2:4. doi: 10.3389/neuro.24.004.2010
02 December 2009;
 Paper pending published:
09 December 2009;
22 January 2010;
 Published online:
12 February 2010.

Edited by:

Thomas C. Foster, University of Florida, USA

Reviewed by:

Pedro Fernandez-Funez, University of Florida, USA
Tony Payton, University of Manchester, UK
© 2010 Schneider, Huentelman, Kremerskothen, Duning, Spoelgen and Nikolich. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.
Armin Schneider, Department of Molecular Neurology, SYGNIS Bioscience, Im Neuenheimer Feld 515, 69120 Heidelberg, Germany. e-mail: schneider@sygnis.de; Karoly Nikolich, Amnestix Incorporated, 800 Airport Boulevard, Suite 314, Burlingame, CA 94010, USA. e-mail: knikolich@amnestix.com