Front. Aging Neurosci., 12 February 2010 | http://dx.doi.org/10.3389/neuro.24.004.2010
SYGNIS Bioscience, Heidelberg, Germany
The Translational Genomics Research Institute, Phoenix, AZ, USA
Department of Molecular Nephrology, University Hospital Münster, Münster, Germany
Amnestix Incorporated, Burlingame, CA, USA
The genetic locus encoding KIBRA, a member of the WWC family of proteins, has recently been shown to be associated with human memory performance through genome-wide single nucleotide polymorphism screening. Gene expression analysis and a variety of functional studies have further indicated that such a role is biologically plausible for KIBRA. Here, we review the existing literature, illustrate connections between the different lines of evidence, and derive models based on KIBRA’s function(s) in the brain that can be further tested experimentally.