The scope of the section embraces a wide range of topics in systems biology, physiology, and medicine, including (but not limited to): dynamics and evolution of metabolic and gene regulatory networks, integrative and computational neuroscience, evolutionary genomics, cell dynamics, organismal development, computational biology, ecosystem dynamics, integrative and behavioural medicine, etc. The section's main focus is on analytical and computational models that are strongly supported and inspired by real biological systems and that integrate current empirical knowledge. Work presenting experimental data without a theoretical or computational modelling component will not be considered and neither will work with theoretical models only tangentially inspired by biological systems.
Indexed in: PubMed, PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef, Chemical Abstracts Service (CAS)
PMCID: all published articles receive a PMCID
Systems Biology welcomes submissions of the following tier 1 articles: Book Review, Clinical Case Study, Clinical Trial, Data Report, Editorial, General Commentary, Hypothesis & Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Protocols, Review, Specialty Grand Challenge and Technology Report.
All manuscripts must be submitted directly to the section Systems Biology, where they are peer reviewed by the associate and review editors of the specialty section.
Articles published in the section Systems Biology will be subject to the Frontiers evaluation system after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a prestigious Frontiers Focused Review - a tier 2 article. This is referred to as "democratic tiering". The author selection is based on article impact analytics of original research published in all Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all of Bioengineering and Biotechnology, Cell and Developmental Biology, Genetics, Neuroscience, Physiology and Psychiatry.