AUTHOR=Marini Herbert , Polito Francesca , Adamo Elena B., Bitto Alessandra , Squadrito Francesco , Benvenga Salvatore TITLE=Update on genistein and thyroid: an overall message of safety JOURNAL=Frontiers in Endocrinology VOLUME=3 YEAR=2012 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2012.00094 DOI=10.3389/fendo.2012.00094 ISSN=1664-2392 ABSTRACT=
Genistein aglycone, one of the soy isoflavones, has been reported to be beneficial in the treatment of menopausal vasomotor symptoms, osteoporosis, and cardiovascular diseases, as well as in a variety of cancers. However, issues of potential harm on thyroid function resulting from soy isoflavones consumption have been raised. Much of the evidence for the goitrogenic effects of isoflavones is derived from experimental