AUTHOR=Hutson John M., Li Ruili , Southwell Bridget R., Petersen Bodil , Thorup Joergen TITLE=Germ cell development in the postnatal testis: the key to prevent malignancy in cryptorchidism? JOURNAL=Frontiers in Endocrinology VOLUME=3 YEAR=2013 URL=https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2012.00176 DOI=10.3389/fendo.2012.00176 ISSN=1664-2392 ABSTRACT=

To permit normal postnatal germ cell development, the mammalian testis undergoes a complex, multi-staged process of descent to the scrotum. Failure of any part of this process leads to congenital cryptorchidism, wherein the malpositioned testis finds itself at the wrong temperature after birth, which leads to secondary germ cell loss and later infertility and risk of cancer. Recent studies suggest that neonatal gonocytes transform into the putative spermatogenic stem cells between 3 and 9 months, and this initial postnatal step is deranged in cryptorchid testes. In addition, it is thought the abnormality high temperature may also impair apoptosis of remaining gonocytes, allowing some to persist to become the possible source of carcinoma in situ and malignancy after puberty. The biology of postnatal germ cell development is of intense interest, as it is likely to be the key to the optimal timing for orchidopexy.