AUTHOR=Zhai Haiyan , Ju Jingfang 

TITLE=Implications of microRNAs in Colorectal Cancer Development, Diagnosis, Prognosis, and Therapeutics

JOURNAL=Frontiers in Genetics

VOLUME=2

YEAR=2011

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2011.00078

DOI=10.3389/fgene.2011.00078

ISSN=1664-8021

ABSTRACT=<p>MicroRNAs (miRNAs) are a class of non-coding small RNAs with critical regulatory functions as post-transcriptional regulators. Due to the fundamental importance and broad impact of miRNAs on multiple genes and pathways, dysregulated miRNAs have been associated with human diseases, including cancer. Colorectal cancer (CRC) is among the most deadly diseases, and miRNAs offer a new frontier for target discovery and novel biomarkers for both diagnosis and prognosis. In this review, we summarize the recent advancement of miRNA research in CRC, in particular, the roles of miRNAs in CRC stem cells, epithelial-to-mesenchymal transition, chemoresistance, therapeutics, diagnosis, and prognosis.</p>