AUTHOR=Sinha Priyanka , Dincer Aslihan , Virgil Daniel , Xu Guang , Poh Yu-Ping , Jensen Jeffrey D. TITLE=On Detecting Selective Sweeps Using Single Genomes JOURNAL=Frontiers in Genetics VOLUME=2 YEAR=2011 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2011.00085 DOI=10.3389/fgene.2011.00085 ISSN=1664-8021 ABSTRACT=
Identifying the genetic basis of human adaptation has remained a central focal point of modern population genetics. One major area of interest has been the use of polymorphism data to detect so-called “footprints” of selective sweeps – patterns produced as a beneficial mutation arises and rapidly fixes in the population. Based on numerous simulation studies and power analyses, the necessary sample size for achieving appreciable power has been shown to vary from a few individuals to a few dozen, depending on the test statistic. And yet, the sequencing of multiple copies of a single region, or of multiple genomes as is now often the case, incurs considerable cost. Enard et al. (