AUTHOR=Spadaro Paola , Bredy Timothy W.

TITLE=Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders

JOURNAL=Frontiers in Genetics

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2012.00132

DOI=10.3389/fgene.2012.00132

ISSN=1664-8021

ABSTRACT=<p>Non-coding RNAs (ncRNAs) have emerged as critical regulators of transcription, epigenetic processes, and gene silencing, which make them ideal candidates for insight into molecular evolution and a better understanding of the molecular pathways of neuropsychiatric disease. Here, we provide an overview of the current state of knowledge regarding various classes of ncRNAs and their role in neural plasticity and cognitive function, and highlight the potential contribution they may make to the development of a variety of neuropsychiatric disorders, including schizophrenia, addiction, and fear-related anxiety disorders.</p>