AUTHOR=Li Yan-yan , Lu Xin-zheng , Wang Hui , Zhou Yan-hong , Yang Xin-xing , Geng Hong-yu , Gong Ge , Kim Hyun Jun 

TITLE=ADRB3 Gene Trp64Arg Polymorphism and Essential Hypertension: A Meta-Analysis Including 9,555 Subjects

JOURNAL=Frontiers in Genetics

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2018.00106

DOI=10.3389/fgene.2018.00106

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> Presence of the β<italic>3-Adrenergic receptor (ADRB3)</italic> gene Trp64Arg (T64A) polymorphism may be associated with an increased susceptibility for essential hypertension (EH). A clear consensus, however, has yet to be reached.</p><p><bold>Objective and methods:</bold> To further elucidate the relationship between the <italic>ADRB3</italic> gene Trp64Arg polymorphism and EH, a meta-analysis of 9,555 subjects aggregated from 16 individual studies was performed. The combined odds ratios (ORs) and their corresponding 95% confidence intervals (CI) were evaluated using either a random or fixed effect model.</p><p><bold>Results:</bold> We found a marginally significant association between <italic>ADRB3</italic> gene Trp64Arg polymorphism and EH in the whole population under the additive genetic model (OR: 1.200, 95% CI: 1.00–1.43, <italic>P</italic> = 0.049). Association within the Chinese subgroup, however, was significant under allelic (OR: 1.150, 95% CI: 1.002–1.320, <italic>P</italic> = 0.046), dominant (OR: 1.213, 95% CI: 1.005–1.464, <italic>P</italic> = 0.044), heterozygous (OR: 1.430, 95% CI:1.040–1.970, <italic>P</italic> = 0.03), and additive genetic models (OR: 1.280, 95% CI: 1.030–1.580, <italic>P</italic> = 0.02). A significant association was also found in the Caucasian subgroup under allelic (OR: 1.850, 95% CI: 1. 260–2.720, <italic>P</italic> = 0.002), dominant (OR: 2.004, 95% CI: 1.316–3.052, <italic>P</italic> = 0.001), heterozygous (OR: 2.220, 95% CI: 1.450–3.400, <italic>P</italic> = 0.0002), and additive genetic models (OR: 2.000, 95% CI: 1. 330–3.010, <italic>P</italic> = 0.0009).</p><p><bold>Conclusions:</bold> The presence of the <italic>ADRB3</italic> gene Trp64Arg polymorphism is positively associated with EH, especially in the Chinese and Caucasian population. The Arg allele carriers of <italic>ADRB3</italic> gene Trp64Arg polymorphism may be at an increased risk for developing EH.</p>