AUTHOR=Turner Stephen J., Russ Brendan E., Denton Alice E., Hatton Lauren , Croom Hayley , Olson Matthew R.

TITLE=Defining the molecular blueprint that drives CD8+ T cell differentiation in response to infection

JOURNAL=Frontiers in Immunology

VOLUME=3

YEAR=2012

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00371

DOI=10.3389/fimmu.2012.00371

ISSN=1664-3224

ABSTRACT=<p>A cardinal feature of adaptive, cytotoxic T lymphocyte (CTL)-mediated immunity is the ability of naïve CTLs to undergo a program of differentiation and proliferation upon activation resulting in the acquisition of lineage-specific T cell functions and eventual establishment of immunological memory. In this review, we examine the molecular factors that shape both the acquisition and maintenance of lineage-specific effector function in virus-specific CTL during both the effector and memory phases of immunity.</p>