AUTHOR=Howson Lauren J. , Salio Mariolina , Cerundolo Vincenzo 

TITLE=MR1-Restricted Mucosal-Associated Invariant T Cells and Their Activation during Infectious Diseases

JOURNAL=Frontiers in Immunology

VOLUME=6

YEAR=2015

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00303

DOI=10.3389/fimmu.2015.00303

ISSN=1664-3224

ABSTRACT=<p>MR1-restricted mucosal-associated invariant T (MAIT) cells recognize vitamin B metabolites, which are generated by a broad range of bacteria, from <italic>Escherichia coli</italic> to <italic>Mycobacterium tuberculosis</italic> and BCG. MAIT cells have been described as innate sensors of infection as they accumulate early in infected tissues. MAIT cells maintain an activated phenotype throughout the course of infections, secrete inflammatory cytokines, and have the potential to directly kill infected cells, playing an important role in shaping the host response. In this review, we will discuss the current knowledge regarding the molecular mechanisms that underline MAIT cells activation in sterile and non-sterile inflammatory conditions.</p>