AUTHOR=Zenclussen Ana Claudia , Hämmerling Günter J. TITLE=Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation JOURNAL=Frontiers in Immunology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00321 DOI=10.3389/fimmu.2015.00321 ISSN=1664-3224 ABSTRACT=

Implantation of the fertilized egg into the maternal uterus is a crucial step in pregnancy establishment. Increasing evidence suggests that its success depends on various cell types of the innate immune system and on the fine balance between inflammatory and anti-inflammatory processes. In addition, it has recently been established that regulatory T cells play a superordinate role in dictating the quality of uterine environment required for successful pregnancy. Here, we discuss the cellular regulation of uterine receptivity with emphasis on the function and regulation of cells from the innate and adaptive immune system.