AUTHOR=Gutiérrez-Martínez Enric , Planès Remi , Anselmi Giorgio , Reynolds Matthew , Menezes Shinelle , Adiko Aimé Cézaire , Saveanu Loredana , Guermonprez Pierre TITLE=Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets JOURNAL=Frontiers in Immunology VOLUME=6 YEAR=2015 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2015.00363 DOI=10.3389/fimmu.2015.00363 ISSN=1664-3224 ABSTRACT=

Dendritic cells (DCs) have the unique ability to pick up dead cells carrying antigens in tissue and migrate to the lymph nodes where they can cross-present cell-associated antigens by MHC class I to CD8+ T cells. There is strong in vivo evidence that the mouse XCR1+ DCs subset acts as a key player in this process. The intracellular processes underlying cross-presentation remain controversial and several pathways have been proposed. Indeed, a wide number of studies have addressed the cellular process of cross-presentation in vitro using a variety of sources of antigen and antigen-presenting cells. Here, we review the in vivo and in vitro evidence supporting the current mechanistic models and disscuss their physiological relevance to the cross-presentation of cell-associated antigens by DCs subsets.