AUTHOR=Tamura Yasuaki , Yoneda Akihiro , Takei Norio , Sawada Kaori 

TITLE=Spatiotemporal Regulation of Hsp90–Ligand Complex Leads to Immune Activation

JOURNAL=Frontiers in Immunology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2016.00201

DOI=10.3389/fimmu.2016.00201

ISSN=1664-3224

ABSTRACT=<p>Although heat shock proteins (HSPs) primarily play a pivotal role in the maintenance of cellular homeostasis while reducing extracellular as well as intracellular stresses, their role in immunologically relevant scenarios, including activation of innate immunity as danger signals, antitumor immunity, and autoimmune diseases, is now gaining much attention. The most prominent feature of HSPs is that they function both in their own and as an HSP–ligand complex. We here show as a unique feature of extracellular HSPs that they target chaperoned molecules into a particular endosomal compartment of dendritic cells, thereby inducing innate and adaptive immune responses via spatiotemporal regulation.</p>