AUTHOR=Murrieta-Coxca José Martin , Gómez-Chávez Fernando , Baeza-Martínez Damariz Adriana , Cancino-Diaz Mario Eugenio , Cancino-Diaz Juan Carlos , Pérez-Tapia Sonia Mayra , Reyes-Maldonado Elba , Rodríguez-Martínez Sandra TITLE=Estrous Cycle and Gestational Age-Dependent Expression of Members of the Interleukin-36 Subfamily in a Semi-Allogeneic Model of Infected and Non-Infected Murine Pregnancy JOURNAL=Frontiers in Immunology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2016.00376 DOI=10.3389/fimmu.2016.00376 ISSN=1664-3224 ABSTRACT=
The IL-36 subfamily is a recently described group of cytokines with pro-inflammatory behavior, comprising three agonists (α, β, and γ), its receptor (R), and one antagonist (Ra). The expression and function of IL-36 subfamily members in the estrous cycle in healthy and infected pregnancy has not been described. We evaluated mRNA and protein expression of IL-36 family members during the estrous cycle, implantation, fetal development, and post-labor periods in a model of allogenic pregnancy in mice. We also explored the ability of