AUTHOR=Reis Monica , Ogonek Justyna , Qesari Marsela , Borges Nuno M. , Nicholson Lindsay , Preußner Liane , Dickinson Anne Mary , Wang Xiao-nong , Weissinger Eva M. , Richter Anne TITLE=Recent Developments in Cellular Immunotherapy for HSCT-Associated Complications JOURNAL=Frontiers in Immunology VOLUME=7 YEAR=2016 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2016.00500 DOI=10.3389/fimmu.2016.00500 ISSN=1664-3224 ABSTRACT=

Allogeneic hematopoietic stem cell transplantation is associated with serious complications, and improvement of the overall clinical outcome of patients with hematological malignancies is necessary. During the last decades, posttransplant donor-derived adoptive cellular immunotherapeutic strategies have been progressively developed for the treatment of graft-versus-host disease (GvHD), infectious complications, and tumor relapses. To date, the common challenge of all these cell-based approaches is their implementation for clinical application. Establishing an appropriate manufacturing process, to guarantee safe and effective therapeutics with simultaneous consideration of economic requirements is one of the most critical hurdles. In this review, we will discuss the recent scientific findings, clinical experiences, and technological advances for cell processing toward the application of mesenchymal stromal cells as a therapy for treatment of severe GvHD, virus-specific T cells for targeting life-threating infections, and of chimeric antigen receptors-engineered T cells to treat relapsed leukemia.