AUTHOR=Himly Martin , Mills-Goodlet Robert , Geppert Mark , Duschl Albert 

TITLE=Nanomaterials in the Context of Type 2 Immune Responses—Fears and Potentials

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00471

DOI=10.3389/fimmu.2017.00471

ISSN=1664-3224

ABSTRACT=<p>The type 2 immune response is an adaptive immune program involved in defense against parasites, detoxification, and wound healing, but is predominantly known for its pathophysiological effects, manifesting as allergic disease. Engineered nanoparticles (NPs) are non-self entities that, to our knowledge, do not stimulate detrimental type 2 responses directly, but have the potential to modulate ongoing reactions in various ways, including the delivery of substances aiming at providing a therapeutic benefit. We review, here, the state of knowledge concerning the interaction of NPs with type 2 immune responses and highlight their potential as a multifunctional platform for therapeutic intervention.</p>