AUTHOR=Liu Yan-Cun , Yu Mu-Ming , Shou Song-Tao , Chai Yan-Fen 

TITLE=Sepsis-Induced Cardiomyopathy: Mechanisms and Treatments

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01021

DOI=10.3389/fimmu.2017.01021

ISSN=1664-3224

ABSTRACT=<p>Sepsis is a lethal syndrome with a high incidence and a weighty economy burden. The pathophysiology of sepsis includes inflammation, immune dysfunction, and dysfunction of coagulation, while sepsis-induced cardiomyopathy (<italic>SIC</italic>), defined as a global but reversible dysfunction of both sides of the heart induced by sepsis, plays a significant role in all of the aspects above in the pathogenesis of sepsis. The complex pathogenesis of <italic>SIC</italic> involves a combination of dysregulation of inflammatory mediators, mitochondrial dysfunction, oxidative stress, disorder of calcium regulation, autonomic nervous system dysregulation, and endothelial dysfunction. The treatments for <italic>SIC</italic> include the signal pathway intervention, Chinese traditional medicine, and other specific therapy. Here, we reviewed the latest literatures on the mechanisms and treatments of <italic>SIC</italic> and hope to provide further insights to researchers and create a new road for the therapy of sepsis.</p>