AUTHOR=Górski Andrzej , Jończyk-Matysiak Ewa , Międzybrodzki Ryszard , Weber-Dąbrowska Beata , Borysowski Jan 

TITLE=“Phage Transplantation in Allotransplantation”: Possible Treatment in Graft-Versus-Host Disease?

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00941

DOI=10.3389/fimmu.2018.00941

ISSN=1664-3224

ABSTRACT=<p>Graft-versus-host disease, both acute and chronic (aGvHD, cGvHD) remains a major complication in patients undergoing hematopoietic cell transplantation (HCT) and a significant therapeutic challenge, as many patients do not respond adequately to presently available therapy. Increasing antimicrobial resistance has greatly revived interest in using bacterial viruses (phages) to combat antibiotic-resistant bacteria. In recent years, evidence has accumulated indicating that phages also have anti-inflammatory and immunomodulatory activities. This article suggests how these anti-bacterial and immunomodulatory activities of phages may be translated into a novel treatment of acute GvHD.</p>