AUTHOR=Malik Kale Preeti , Jolly Carrie E., Lathrop Stephanie , Winfree Seth , Luterbach Courtney , Steele-Mortimer Olivia 

TITLE=Salmonella – At Home in the Host Cell

JOURNAL=Frontiers in Microbiology

VOLUME=2

YEAR=2011

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2011.00125

DOI=10.3389/fmicb.2011.00125

ISSN=1664-302X

ABSTRACT=<p>The Gram-negative bacterium <italic>Salmonella enterica</italic> has developed an array of sophisticated tools to manipulate the host cell and establish an intracellular niche, for successful propagation as a facultative intracellular pathogen. While <italic>Salmonella</italic> exerts diverse effects on its host cell, only the cell biology of the classic “trigger”-mediated invasion process and the subsequent development of the <italic>Salmonella</italic>-containing vacuole have been investigated extensively. These processes are dependent on cohorts of effector proteins translocated into host cells by two type III secretion systems (T3SS), although T3SS-independent mechanisms of entry may be important for invasion of certain host cell types. Recent studies into the intracellular lifestyle of <italic>Salmonella</italic> have provided new insights into the mechanisms used by this pathogen to modulate its intracellular environment. Here we discuss current knowledge of <italic>Salmonella</italic>-host interactions including invasion and establishment of an intracellular niche within the host.</p>