AUTHOR=Pérez-Reytor Diliana , Plaza Nicolás , Espejo Romilio T. , Navarrete Paola , Bastías Roberto , Garcia Katherine 

TITLE=Role of Non-coding Regulatory RNA in the Virulence of Human Pathogenic Vibrios

JOURNAL=Frontiers in Microbiology

VOLUME=7

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2016.02160

DOI=10.3389/fmicb.2016.02160

ISSN=1664-302X

ABSTRACT=<p>In recent decades, the identification of small non-coding RNAs in bacteria has revealed an important regulatory mechanism of gene expression involved in the response to environmental signals and to the control of virulence. In the family <italic>Vibrionaceae</italic>, which includes several human and animal pathogens, small non-coding RNAs (sRNAs) are closely related to important processes including metabolism, quorum sensing, virulence, and fitness. Studies conducted <italic>in silico</italic> and experiments using microarrays and high-throughput RNA sequencing have led to the discovery of an unexpected number of sRNAs in <italic>Vibrios</italic>. The present review discusses the most relevant reports regarding the mechanisms of action of sRNAs and their implications in the virulence of the main human pathogens in the family <italic>Vibrionaceae: Vibrio parahaemolyticus, V. vulnificus</italic> and <italic>V. cholerae</italic>.</p>