AUTHOR=Yap Theresa Wan-Chen , Leow Alex Hwong-Ruey , Azmi Ahmad Najib , Callahan Damien L. , Perez-Perez Guillermo I. , Loke Mun-Fai , Goh Khean-Lee , Vadivelu Jamuna 

TITLE=Global Fecal and Plasma Metabolic Dynamics Related to Helicobacter pylori Eradication

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00536

DOI=10.3389/fmicb.2017.00536

ISSN=1664-302X

ABSTRACT=<p><bold>Background:</bold><italic>Helicobacter pylori</italic> colonizes the gastric mucosa of more than half of the world's population. There is increasing evidence <italic>H. pylori</italic> protects against the development of obesity and childhood asthma/allergies in which the development of these diseases coincide with transient dysbiosis. However, the mechanism underlying the association of <italic>H. pylori</italic> eradication with human metabolic and immunological disorders is not well-established. In this study, we aimed to investigate the local and systemic effects of <italic>H. pylori</italic> eradication through untargeted fecal lipidomics and plasma metabolomics approaches by liquid chromatography mass spectrometry (LC-MS).</p><p><bold>Results:</bold> Our study revealed that eradication of <italic>H. pylori</italic> eradication (i.e., loss of <italic>H. pylori</italic> and/or <italic>H. pylori</italic> eradication therapy) changed many global metabolite/lipid features, with the majority being down-regulated. Our findings primarily show that <italic>H. pylori</italic> eradication affects the host energy and lipid metabolism which may eventually lead to the development of metabolic disorders.</p><p><bold>Conclusion:</bold> These predictive metabolic signatures of metabolic and immunological disorders following <italic>H. pylori</italic> eradication can provide insights into dynamic local and systemic metabolism related to <italic>H. pylori</italic> eradication in modulating human health.</p>