AUTHOR=Zhan Lingjun , Tang Jun , Sun Mengmeng , Qin Chuan 

TITLE=Animal Models for Tuberculosis in Translational and Precision Medicine

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00717

DOI=10.3389/fmicb.2017.00717

ISSN=1664-302X

ABSTRACT=<p>Tuberculosis (TB) is a health threat to the global population. Anti-TB drugs and vaccines are key approaches for TB prevention and control. TB animal models are basic tools for developing biomarkers of diagnosis, drugs for therapy, vaccines for prevention and researching pathogenic mechanisms for identification of targets; thus, they serve as the cornerstone of comparative medicine, translational medicine, and precision medicine. In this review, we discuss the current use of TB animal models and their problems, as well as offering perspectives on the future of these models.</p>