AUTHOR=Bajpai Vivek K. , Shukla Shruti , Paek Woon K. , Lim Jeongheui , Kumar Pradeep , Kumar Pankaj , Na MinKyun 

TITLE=Efficacy of (+)-Lariciresinol to Control Bacterial Growth of Staphylococcus aureus and Escherichia coli O157:H7

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.00804

DOI=10.3389/fmicb.2017.00804

ISSN=1664-302X

ABSTRACT=<p>This study was undertaken to assess the antibacterial potential of a polyphenolic compound (+)-lariciresinol isolated from <italic>Rubia philippinensis</italic> against selected foodborne pathogens <italic>Staphylococcus aureus</italic> KCTC1621 and <italic>Escherichia coli</italic> O157:H7. (+)-Lariciresinol at the tested concentrations (250 μg/disk) evoked a significant antibacterial effect as a diameter of inhibition zones (12.1–14.9 mm) with minimum inhibitory concentration (MIC), and minimum bactericidal concentration values of 125–250 and 125–250 μg/mL, respectively. Furthermore, (+)-lariciresinol at MIC showed reduction in bacterial cell viabilities, efflux of potassium (K<sup>+</sup>) ions and release of 260 nm materials against <italic>E. coli</italic> O157:H7 and <italic>S. aureus</italic> KCTC1621. Moreover, deteriorated cell wall morphology of <italic>E. coli</italic> O157:H7 and <italic>S. aureus</italic> KCTC1621 cells treated with (+)-lariciresinol at MIC further confirmed its inhibitory effect against the tested pathogens, suggesting it to be an alternative means of antimicrobials.</p>