AUTHOR=Yang Yan , He Jun-Jun , Hu Shuang , Chang Hua , Xiang Xun , Yang Jian-Fa , Zou Feng-Cai 

TITLE=Comparative Study of Transcriptome Profiles of Mouse Livers and Skins Infected by Fork-Tailed or Non-Fork-Tailed Schistosoma japonicum

JOURNAL=Frontiers in Microbiology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2017.01648

DOI=10.3389/fmicb.2017.01648

ISSN=1664-302X

ABSTRACT=<p><italic>Schistosoma japonicum</italic> (<italic>S. japonicum</italic>) is a worldwide spread pathogen which penetrates host skin and then induces several diseases in infected host, such as fibrosis, formation of granulomas, hepatocirrhosis, and hepatomegaly. In present study, for the first time, transcriptomic profiles of mouse livers and skins infected by fork-tailed <italic>S. japonicum</italic> cercaria or non-fork-tailed <italic>S. japonicum</italic> cercaria were analyzed by using RNA-seq. The present findings demonstrated that transcriptomic landscapes of livers and skins infected by fork-tailed <italic>S. japonicum</italic> cercaria or non-fork-tailed <italic>S. japonicum</italic> cercaria were different. <italic>S. japonicum</italic> has great influence on hepatic metabolic processes. Fork-tailed <italic>S. japonicum</italic> cercaria upregulated hepatic metabolic processes, while non-fork-tailed <italic>S. japonicum</italic> cercaria downregulated hepatic metabolic processes. For the metabolism process or the metabolism enzyme expressional change, the pharmacokinetics of host could be changed during <italic>S. japonicum</italic> infection, regardless the biotypes of <italic>S. japonicum</italic> cercariae. The changes of infected skins focused on upregulation of immune response. During the <italic>S. japonicum</italic> skin infection period, fork-tailed <italic>S. japonicum</italic> cercaria infection induced stronger immune response comparing with that immune response triggered by non-fork-tailed <italic>S. japonicum</italic> cercaria. The transcription factor enrichment analysis showed that Irf7, Stat1 and Stat2 could play important roles in gene regulation during fork-tailed <italic>S. japonicum</italic> cercaria infection.</p>